In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2020-12-21), p. e1009176-
Abstract:
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are known to modulate the severity and progression of chronic inflammatory diseases. The tyrosine kinase receptors TYRO3, AXL, and MERTK (TAM) have been described as inhibitors of the immune response in various inflammatory settings. We show here that patients with concurrent natural helminth infections and MS condition (HIMS) had an increased expression of the negative regulatory TAM receptors in antigen-presenting cells and their agonist GAS6 in circulating CD11b high and CD4 + T cells compared to patients with only MS. The Th17 subset was reduced in patients with HIMS with a subsequent downregulation of its pathogenic genetic program. Moreover, these CD4 + T cells promoted lower levels of the co-stimulatory molecules CD80, CD86, and CD40 on dendritic cells compared with CD4 + T cells from patients with MS, an effect that was GAS6-dependent. IL-10 + cells from patients with HIMS showed higher GAS6 expression levels than Th17 cells, and inhibition of phosphatidylserine/GAS6 binding led to an expansion of Th17 effector genes. The addition of GAS6 on activated CD4 + T cells from patients with MS restrains the Th17 gene expression signature. This cohort of patients with HIMS unravels a promising regulatory mechanism to dampen the Th17 inflammatory response in autoimmunity.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009176
DOI:
10.1371/journal.ppat.1009176.g001
DOI:
10.1371/journal.ppat.1009176.g002
DOI:
10.1371/journal.ppat.1009176.g003
DOI:
10.1371/journal.ppat.1009176.g004
DOI:
10.1371/journal.ppat.1009176.g005
DOI:
10.1371/journal.ppat.1009176.g006
DOI:
10.1371/journal.ppat.1009176.t001
DOI:
10.1371/journal.ppat.1009176.s001
DOI:
10.1371/journal.ppat.1009176.s002
DOI:
10.1371/journal.ppat.1009176.s003
DOI:
10.1371/journal.ppat.1009176.s004
DOI:
10.1371/journal.ppat.1009176.s005
DOI:
10.1371/journal.ppat.1009176.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2205412-1