In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-3), p. e0278454-
Abstract:
Liver metastases are common in patients with breast cancer, and determining the factors associated with such metastases may improve both their early detection and treatment. Given that liver function protein level changes in these patients have not been determined, the aim of our study was to investigate liver function protein level changes over time, spanning 6 months before the detection of liver metastasis to 12 months after. Methods We retrospectively studied 104 patients with hepatic metastasis from breast cancer who were treated at the Departments of Internal Medicine I and the Department of Obstetrics and Gynecology at the Medical University of Vienna between 1980 and 2019. Data were extracted from patient records. Results Aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, lactate dehydrogenase and alkaline phosphatase were significantly elevated when compared to normal range 6 months before the detection of liver metastases ( p 〈 0.001) Albumin was decreased ( p 〈 0.001). The values of aspartate aminotransferase, gamma-glutamyltransferase, and lactate dehydrogenase were significantly increased at the time of diagnosis compared to 6 months prior ( p 〈 0.001). Patient- and tumor-specific parameters had no influence on these liver function indicators. Elevated aspartate aminotransferase ( p = 0.002) and reduced albumin ( p = 0.002) levels at the time of diagnosis were associated with shorter overall survival. Conclusion Liver function protein levels should be considered as potential indicators when screening for liver metastasis in patients with breast cancer. With the new treatment options available, it could lead to prolonged life.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278454
DOI:
10.1371/journal.pone.0278454.g001
DOI:
10.1371/journal.pone.0278454.g002
DOI:
10.1371/journal.pone.0278454.g003
DOI:
10.1371/journal.pone.0278454.t001
DOI:
10.1371/journal.pone.0278454.s001
DOI:
10.1371/journal.pone.0278454.s002
DOI:
10.1371/journal.pone.0278454.s003
DOI:
10.1371/journal.pone.0278454.s004
DOI:
10.1371/journal.pone.0278454.s005
DOI:
10.1371/journal.pone.0278454.r001
DOI:
10.1371/journal.pone.0278454.r002
DOI:
10.1371/journal.pone.0278454.r003
DOI:
10.1371/journal.pone.0278454.r004
DOI:
10.1371/journal.pone.0278454.r005
DOI:
10.1371/journal.pone.0278454.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3