In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-14), p. e0270839-
Abstract:
In an empirical analysis of transposable element (TE) abundance within natural populations of Mimulus guttatus and Drosophila melanogaster , we found a surprisingly high variance of TE count (e.g., variance-to-mean ratio on the order of 10 to 300). To obtain insight regarding the evolutionary genetic mechanisms that underlie the overdispersed population distributions of TE abundance, we developed a mathematical model of TE population genetics that includes the dynamics of element proliferation and purifying selection on TE load. The modeling approach begins with a master equation for a birth-death process and extends the predictions of the classical theory of TE dynamics in several ways. In particular, moment-based analyses of population distributions of TE load reveal that overdispersion is likely to arise via copy-and-paste proliferation dynamics, especially when the elementary processes of proliferation and excision are approximately balanced. Parameter studies and analytic work confirm this result and further suggest that overdispersed population distributions of TE abundance are probably not a consequence of purifying selection on total element load.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0270839
DOI:
10.1371/journal.pone.0270839.g001
DOI:
10.1371/journal.pone.0270839.g002
DOI:
10.1371/journal.pone.0270839.g003
DOI:
10.1371/journal.pone.0270839.g004
DOI:
10.1371/journal.pone.0270839.g005
DOI:
10.1371/journal.pone.0270839.g006
DOI:
10.1371/journal.pone.0270839.g007
DOI:
10.1371/journal.pone.0270839.g008
DOI:
10.1371/journal.pone.0270839.t001
DOI:
10.1371/journal.pone.0270839.t002
DOI:
10.1371/journal.pone.0270839.s001
DOI:
10.1371/journal.pone.0270839.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3