In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-23), p. e0256521-
Abstract:
To examine subgroup-specific treatment preferences and characteristics of patients with hemophilia A. Methods Best–Worst Scaling (BWS) Case 3 (four attributes: application type; bleeding frequencies/year; inhibitor development risk; thromboembolic events of hemophilia A treatment risk) conducted via online survey. Respondents chose the best and the worst option of three treatment alternatives. Data were analyzed via latent class model (LCM), allowing capture of heterogeneity in the sample. Respondents were grouped into a predefined number of classes with distinct preferences. Results The final dataset contained 57 respondents. LCM analysis segmented the sample into two classes with heterogeneous preferences. Preferences within each were homogeneous. For class 1, the most decisive factor was bleeding frequency/year. Respondents seemed to focus mainly on this in their choice decisions. With some distance, inhibitor development was the second most important. The remaining attributes were of far less importance for respondents in this class. Respondents in class 2 based their choice decisions primarily on inhibitor development, also followed, by some distance, the second most important attribute bleeding frequency/year. There was statistical significance (P 〈 0.05) between the number of annual bleedings and the probability of class membership. Conclusions The LCM analysis addresses heterogeneity in respondents’ choice decisions, which helps to tailor treatment alternatives to individual needs. Study results support clinical and allocative decision-making and improve the quality of interpretation of clinical data.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0256521
DOI:
10.1371/journal.pone.0256521.g001
DOI:
10.1371/journal.pone.0256521.t001
DOI:
10.1371/journal.pone.0256521.s001
DOI:
10.1371/journal.pone.0256521.s002
DOI:
10.1371/journal.pone.0256521.s003
DOI:
10.1371/journal.pone.0256521.s004
DOI:
10.1371/journal.pone.0256521.s005
DOI:
10.1371/journal.pone.0256521.s006
DOI:
10.1371/journal.pone.0256521.r001
DOI:
10.1371/journal.pone.0256521.r002
DOI:
10.1371/journal.pone.0256521.r003
DOI:
10.1371/journal.pone.0256521.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3