In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-23), p. e0247359-
Kurzfassung:
The prognosis of stented lesions differs according to in-stent neointimal characteristics on optical coherence tomography (OCT). In particular, patients who show in-stent heterogeneous neointima are associated with a higher incidence of target lesion revascularization (TLR) compared with those who show in-stent non-heterogeneous neointima. However, the relationship between in-stent neointimal characteristics and native coronary atherosclerosis progression has not been clearly elucidated. The study aimed to investigate the relationship between in-stent neointimal characteristics and progression of native atherosclerosis. Methods The neointimal characteristics of 377 patients with 377 drug-eluting stents (DESs) were quantitatively and qualitatively assessed using OCT. The OCT-based neointima was categorized as homogeneous (n = 207), heterogeneous (n = 93), and layered (n = 77). The relationship of non-target lesion revascularization (non-TLR) with neointimal characteristics was evaluated after OCT examination of the stents. Results After a median follow-up duration of 40.0 months, patients with heterogeneous neointima showed significantly higher non-TLR rates than those with homogeneous neointima and tended to have higher non-TLR rates than those with layered neointima (heterogeneous vs. homogeneous:14.0% vs. 8.7%, p = 0.046; heterogeneous vs. layered neointima:14.0% vs. 7.8%, p = 0.152). Multivariate analysis showed that the independent determinants for non-TLR were heterogeneous neointima (HR: 2.237, 95% CI: 1.023–4.890, p = 0.044) and chronic kidney disease (hazard ratio [HR]: 8.730, 95% CI: 2.175–35.036, p = 0.002). Conclusions The heterogeneous neointima in DES-treated lesions was associated with a higher incidence of non-TLR and target lesion failure. This finding suggests that the neointimal pattern may reflect the progression of the native lesion.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0247359
DOI:
10.1371/journal.pone.0247359.g001
DOI:
10.1371/journal.pone.0247359.g002
DOI:
10.1371/journal.pone.0247359.g003
DOI:
10.1371/journal.pone.0247359.t001
DOI:
10.1371/journal.pone.0247359.t002
DOI:
10.1371/journal.pone.0247359.t003
DOI:
10.1371/journal.pone.0247359.t004
DOI:
10.1371/journal.pone.0247359.s001
DOI:
10.1371/journal.pone.0247359.s002
DOI:
10.1371/journal.pone.0247359.s003
DOI:
10.1371/journal.pone.0247359.s004
DOI:
10.1371/journal.pone.0247359.r001
DOI:
10.1371/journal.pone.0247359.r002
DOI:
10.1371/journal.pone.0247359.r003
DOI:
10.1371/journal.pone.0247359.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2267670-3