In:
Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 97, No. 4 ( 2015-04-01), p. 797-805
Abstract:
There has been increasing evidence that chronic immune activation plays critical roles in the pathogenesis of DCM. CD4+ LAP+ Tregs are a newly identified T cell subset with suppressive function on the immune response. This study was designed to investigate whether the circulating frequency and function of CD4+LAP+ Tregs would be impaired in patients with DCM. The results demonstrated that DCM patients had a significantly lower frequency of circulating CD4+LAP+ Tregs compared with control donors. CD4+LAP+ Tregs from DCM patients showed compromised function to suppress proliferation of CD4+ LAP−CD25int/low T cells and proliferation and IgG production of B cells. Moreover, B cell proliferation and IgG subset production could be directly suppressed by CD4+ LAP+ Tregs. TGF-β and contact-dependent mechanisms were involved in CD4+LAP+ Treg-mediated suppression. Correlation analysis suggested that CD4+LAP+ Treg frequency was positively correlated with LVEF and negatively correlated with serum IgG3 and NT-proBNP concentration in patients with DCM. Our results are the first to demonstrate that the frequencies of CD4+LAP+ Tregs in patients with DCM are reduced and that their suppressive function is compromised. Defective CD4+ LAP+ Tregs may be an underlying mechanism of immune activation in DCM patients.
Type of Medium:
Online Resource
ISSN:
0741-5400
,
1938-3673
DOI:
10.1189/jlb.5A1014-469RR
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2015
detail.hit.zdb_id:
2026833-6
SSG:
12
