In:
BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
Abstract:
The association between prothrombin time-international normalized ratio (PT-INR) and long-term prognosis among patients with coronary artery disease (CAD) without atrial fibrillation or anticoagulant therapy was still unclear. We analyzed the association of PT-INR levels and long-term mortality in a large cohort of CAD patients without atrial fibrillation or using of anticoagulant drugs. Methods We obtained data from 44,662 patients who were diagnosed with CAD and had follow-up information from January 2008 to December 2018. The patients were divided into 4 groups (Quartile 1: PT-INR ≤ 0.96; Quartile2: 0.96 〈 PT-INR ≤ 1.01; Quartile3: 1.01 〈 PT-INR ≤ 1.06; Quartile4: PT-INR 〉 1.06). The main endpoint was long-term all-cause death. Kaplan–Meier curve analysis and Cox proportional hazards models were used to investigate the association between quartiles of PT-INR levels and long-term all-cause mortality. Results During a median follow-up of 5.25 years, 5613 (12.57%) patients died. We observed a non-linear shaped association between PT-INR levels and long-term all-cause mortality. Patients in high PT-INR level (Quartile4: PT-INR 〉 1.06) showed a significantly higher long-term mortality than other groups (Quartile2 or 3 or 4), (Compared with Quartile 1, Quartile 2 [0.96 〈 PT-INR ≤ 1.01], aHR = 1.00, 95% CI 0.91–1.00, P = 0.99; Quartile 3 [1.01 〈 PT-INR ≤ 1.06], aHR = 1.10, 95% CI 1.01–1.20, P = 0.03; Quartile 4 [PT-INR 〉 1.06], aHR = 1.33, 95% CI 1.22–1.45, P 〈 0.05). Conclusions Our study demonstrates high levels of PT-INR were associated with an increased risk of all-cause mortality.
Type of Medium:
Online Resource
ISSN:
1471-2261
DOI:
10.1186/s12872-022-02619-4
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2059859-2
