In:
BMC Anesthesiology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
Abstract:
Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combination in colonoscopy. Methods This was a prospective trial carried out at the Fourth Hospital of Hebei Medical University between 02/2018 and 10/2018. The patients were randomized: group I (dexmedetomidine 0.2 μg·kg − 1 ), group II (dexmedetomidine 0.3 μg·kg − 1 ), and group III (dexmedetomidine 0.4 μg·kg − 1 ), all combined with remifentanil. The primary outcomes were the patient’s body movements during the procedure and adverse events. Results Compared with at admission (T 0 ), the SBP, HR, and RR at immediately after giving DEX (T 1 ), at the beginning of the examination (T 2 ), 5 min after the beginning of the examination (T 3 ), 10 min after the beginning of the examination (T 4 ), and at the end of the examination (T 5 ) in the three groups were all reduced (all P 〈 0.05), but all were within the clinically normal range. SpO 2 remained 〉 98% in all patients during the examination. Compared with T 0 , the BIS values of the three groups were decreased at T 1 and T 2 (all P 〈 0.05). There were no significant differences in BIS among the three groups (all P 〉 0.05). The minimum BIS value in group III was lower than in groups I and II ( P 〈 0.05). The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I ( P 〈 0.05). No hypotension occurred, seven patients had bradycardia, and four patients had nausea/vomiting. Conclusions Dexmedetomidine 0.3 μg·kg − 1 combined with remifentanil was effective for colonoscopy and had few adverse reactions. Chinese Clinical Trial Registry: ChiCTR2000029105 , Registered 13 January 2020 - Retrospectively registered.
Type of Medium:
Online Resource
ISSN:
1471-2253
DOI:
10.1186/s12871-020-01141-4
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2091252-3
