In:
BMC Microbiology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
Abstract:
In recent years, clinical Staphylococcus aureus isolates have become highly resistant to antibiotics, which has raised concerns about the ability to control infections by these organisms. The aim of this study was to clarify the effect of a new small molecule, ZY-214-4 (C 19 H 11 BrNO 4 ), on S. aureus pigment production. Results At the concentration of 4 μg/mL, ZY-214-4 exerted a significant inhibitory effect on S. aureus pigment synthesis, without affecting its growth or inducing a toxic effect on the silkworm. An oxidant sensitivity test and a whole-blood killing test indicated that the S. aureus survival rate decreased significantly with ZY-214-4 treatment. Additionally, ZY-214-4 administration significantly reduced the expression of a pigment synthesis-related gene ( crtM ) and the superoxide dismutase genes ( sodA ) as determined by real-time quantitative polymerase chain reaction (RT-qPCR) analysis. ZY-214-4 treatment also improved the survival rate of S. aureus -infected silkworm larvae. Conclusions The small molecule ZY-214-4 has potential for the prevention of S. aureus infections by reducing the virulence associated with this bacterium.
Type of Medium:
Online Resource
ISSN:
1471-2180
DOI:
10.1186/s12866-021-02113-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2041505-9
SSG:
12
