In:
Journal of Ophthalmic Inflammation and Infection, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-11-18)
Abstract:
The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others. Design This investigation is a systematic review and meta-analysis. Methods All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression. Results Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3 rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes. Conclusions Future antibiotic strategies should strongly consider the risks of antibiotic treatment 〉 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.
Type of Medium:
Online Resource
ISSN:
1869-5760
DOI:
10.1186/s12348-022-00317-y
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2592309-2
