In:
Natural Product Communications, SAGE Publications, Vol. 8, No. 2 ( 2013-02), p. 1934578X1300800-
Abstract:
Berberis thunbergii var. atropurpurea. DC is one of the popular landscape plants in the USA, but until now lacked report on its chemical composition and biological properties. In this study, the antioxidant and anti-inflammatory activities of the methanolic extract and pure isolates of B. thunbergii var. atropurpurea, Crimson Pygmy, roots were evaluated using established bioassay procedures. The methanolic extract gave an absorbance value of 0.44 at 250 μg/mL concentration in the MTT assay. In addition, the extract inhibited lipid peroxidation (LPO) by 93% and the cyclooxygenase enzymes, COX-1 by 54 and COX-2 by 34%, at 100 μg/mL concentration. Therefore, a bioactivity-guided purification was carried out yielding pure isolates, out of which compounds 3-6 inhibited LPO by 34-66% at 100 μg/mL concentration. Similarly, compounds 1-6 inhibited COX-1 and −2 by 24-65 and 23-43% at 25 μg/mL concentration, respectively. This is the first report of the chemical constituents and biological activities of this plant.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1300800207
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2430442-6
SSG:
15,3
