In:
Natural Product Communications, SAGE Publications, Vol. 4, No. 9 ( 2009-09), p. 1934578X0900400-
Abstract:
From the methanol extract of Dracaena cambodiana roots two unusual 22S-spirostane steroids (1β,3β,14α,20R,22S,25R)-spirost-5-ene-1,3, 14-triol (1) and (1β,3β,14α,15α,20R,22S,25R)-spirost-5-ene-tetrol (2) have been isolated, together with a known 22R-spirostane compound, namogenin B (3). Their structures were elucidated by spectroscopic and spectrometric methods, including HRMS and extensive 1D and 2D NMR spectroscopy. Compound 1 showed significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Fusarium oxysporum, with MIC values of 45.0, 25.0 and 50.0 μg/mL, respectively.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X0900400908
Language:
English
Publisher:
SAGE Publications
Publication Date:
2009
detail.hit.zdb_id:
2430442-6
SSG:
15,3