In:
The Neuroscientist, SAGE Publications, Vol. 5, No. 3 ( 1999-05), p. 142-146
Abstract:
Cytokines are released during acute and chronic inflammatory diseases of the CNS and activate receptors on glial cells, thereby inducing various effects such as proliferation, expression of major histocompatibility complex genes or secretion of growth factors. Here, we summarize current evidence indicating that K+ currents, Ca 2+ currents, and the activity of ion transporters on astrocytes, microglial cells, and oligodendrocytes are also affected by cytokines. In disease states with associated elevated cytokine titers, such alterations in electrophysiological properties of glial cells might contribute to the patho genesis of neurological symptoms. NEUROSCIENTIST 5:142-146, 1999
Type of Medium:
Online Resource
ISSN:
1073-8584
,
1089-4098
DOI:
10.1177/107385849900500310
Language:
English
Publisher:
SAGE Publications
Publication Date:
1999
detail.hit.zdb_id:
2029471-2
