In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 41, No. 3 ( 2021-03), p. 569-578
Abstract:
Accumulation of amyloid beta (Aβ) is one of the pathological hallmarks of Alzheimer’s disease (AD), which can be visualized using [ 18 F]florbetapir positron emission tomography (PET). The aim of this study was to evaluate various parametric methods and to assess their test-retest (TRT) reliability. Two 90 min dynamic [ 18 F]florbetapir PET scans, including arterial sampling, were acquired ( n = 8 AD patient, n = 8 controls). The following parametric methods were used; (reference:cerebellum); Logan and spectral analysis (SA), receptor parametric mapping (RPM), simplified reference tissue model2 (SRTM2), reference Logan (rLogan) and standardized uptake value ratios (SUV r(50–70) ). BP ND +1, DVR, V T and SUVr were compared with corresponding estimates (V T or DVR) from the plasma input reversible two tissue compartmental (2T4k_V B ) model with corresponding TRT values for 90-scan duration. RPM ( r 2 = 0.92; slope = 0.91), Logan ( r 2 = 0.95; slope = 0.84) and rLogan ( r 2 = 0.94; slope = 0.88), and SRTM2 ( r 2 = 0.91; slope = 0.83), SA ( r 2 = 0.91; slope = 0.88), SUVr ( r 2 = 0.84; slope = 1.16) correlated well with their 2T4k_V B counterparts. RPM (controls: 1%, AD: 3%), rLogan (controls: 1%, AD: 3%) and SUV r(50–70) (controls: 3%, AD: 8%) showed an excellent TRT reliability. In conclusion, most parametric methods showed excellent performance for [ 18 F]florbetapir, but RPM and rLogan seem the methods of choice, combining the highest accuracy and best TRT reliability.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1177/0271678X20915403
Language:
English
Publisher:
SAGE Publications
Publication Date:
2021
detail.hit.zdb_id:
2039456-1
