In:
Angiology, SAGE Publications, Vol. 49, No. 3 ( 1998-03), p. 175-180
Abstract:
To study the mechanism of efficacy of low-density lipoprotein (LDL) adsorption for arte riosclerosis obliterans (ASO), eight ASO patients without indication for bypass surgery underwent LDL apheresis twice a week for 5 weeks and the change in prostaglandin I 2 (PGI 2 ) and thromboxane A 2 (TXA 2 ) due to LDL apheresis was measured. The concentra tion of 6-keto-PGF I ,, a metabolite of PGI 2 , in systemic venous blood significantly increased from 10.4 ± 1.8 to 42.0 ± 10.6 pg/mL (P 〈 0.05) after one session of LDL apheresis, while no significant change of TXB 2 , a metabolite of TXA 2 , was encountered. The ratio of 6-keto-PGF,,,/TXB 2 also rose dramatically from 0.213 ±0.044 to 0.522 ±0.128 (P 〈 0.05) . In five patients, the ischemic clinical symptoms improved and both the concentration of 6-keto-PGF 1α and the ratio of 6-keto-PGF 1α /TXB 2 increased significantly, whereas in three patients there was no effect on clinical symptoms and neither parameter changed. These results suggest that elevated production of PGI 2 from vascular cells due to LDL apheresis might contribute to improvement of ischemic symptoms.
Type of Medium:
Online Resource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/000331979804900302
Language:
English
Publisher:
SAGE Publications
Publication Date:
1998
detail.hit.zdb_id:
2065911-8
