In:
Angiology, SAGE Publications, Vol. 46, No. 5 ( 1995-05), p. 357-367
Abstract:
Skin surface oxygen pressure fields (tcPO 2 [37°C]) reproducibly characterize skin microcirculation in patients with peripheral arterial occlusive disease. These appear suited for investigation of short- and long-term effects of vasoactive drug treatment. The authors studied whether skin surface oxygen pressure histograms change depending on dosage and route of administration of prostaglandin E 1 (PGE 1 ), whether they are of predictive value for patients' clinical outcome, and whether they normalize after therapy with PGE 1 . The authors investigated 15 patients with various degrees of disease and measured forefoot oxygen histograms consisting of at least 80 single tcPO 2 (37°C) values before and during intraarterial infusion (1.5, 3, or 6 ng/kg/minute) and intravenous infusion (4.5, or 9 ng/kg/minute). The measurements were repeated two and six hours after the end of intraarterial application of 1.5 ng/kg/minute. Furthermore, the orthostatic vasoconstrictor response was tested. Skin oxygen pressure histograms were controlled after a period of twenty-two (mean) days of intraarterial PGE 1 therapy. Resting histograms were left shifted with median tcPO 2 (37 ° C) between 1 and 7 mm Hg. During intraarterial application, histograms were shifted to lower tcPO 2 (37 ° C) values in most patients. Only in 3 diabetic subjects with proximal or acral obliterations was a marked increase observed. The alterations were detectable at least two hours after the end of the infusion. During intravenous infusion, histograms did not change in most cases. After long-term therapy, histograms were substantially unchanged. A pathologic vasoconstrictor response, which was present in 10 patients, could not be restored. Despite a marked deterioration of the histograms the clinical outcome was favorable in 7 patients. Patients with a high resting tcPO 2 (37 ° C) (median 4 mm Hg and more) and those with a vasoconstriction on orthostasis are likely to respond to PGE 1 therapy.
Type of Medium:
Online Resource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/000331979504600501
Language:
English
Publisher:
SAGE Publications
Publication Date:
1995
detail.hit.zdb_id:
2065911-8
detail.hit.zdb_id:
80040-5
