In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 129, No. suppl_1 ( 2014-03-25)
Abstract:
Background: Brazil, the 5th largest country in the world, is undergoing a nutrition transition toward unhealthy diets and greater incidence of cardiometabolic diseases (CM). However, little is known about the quantitative impact of major dietary and metabolic risk factors on current burdens of CVD and diabetes in Brazil. Aims: To quantify using consistent and comparable methods the CVD and diabetes mortality attributable to suboptimal diet and metabolic factors in Brazil. Methods: Based on data from 2010 Global Burden of Disease Study, we used a comparative risk assessment framework to develop consistent and comparable methods to identify dietary and metabolic risk factors with evidence for etiologic effects on CVD and diabetes; estimate current national intake levels and their uncertainty, by age and sex; quantify etiologic effects of each diet-disease relationship, by age; and characterize optimal consumption levels. We combined these inputs with national data on disease-specific deaths to estimate overall burdens attributable to each dietary factor, and by age, sex, and disease. We quantified uncertainty using probabilistic simulation analyses, incorporating uncertainty in dietary exposure data and etiologic effects by age, and sex. Missing exposure data was imputed using a multi-level hierarchical Bayesian model based on non-missing exposure data from other regions. Robustness of findings was evaluated by sensitivity to varying inputs including effect sizes and feasible optimal levels. Results: Among dietary factors, low intake of fruits and whole grains had highest impacts on CM mortality, each responsible for ~12% of total CM deaths (62,800 and 61,400 deaths, respectively) (Figure). Hypertension and high fasting plasma glucose were responsible for 32% (163,000) and 28% (141,700) of CM deaths respectively. Other dietary and metabolic risk factors also caused substantial numbers of deaths among Brazilians. Conclusion: Our findings inform priorities for policy measures to reduce CVD and diabetes in Brazil.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.129.suppl_1.p241
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2014
detail.hit.zdb_id:
1466401-X
