In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 5 ( 2006-05), p. 1169-1176
Abstract:
Minimally oxidized low-density lipoprotein (mmLDL) counters macrophage apoptosis induced by extensively oxidized LDL or by free cholesterol loading, both in cell culture and in vivo. The mmLDL activates a pro-survival PI3K/Akt signaling pathway, and PI3K inhibitors eliminate the pro-survival effect of mmLDL. Immunohistochemical examination demonstrates phospho-Akt in murine atherosclerotic lesions.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/01.ATV.0000210279.97308.9a
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2006
detail.hit.zdb_id:
1494427-3