In:
Oncology, S. Karger AG
Abstract:
Introduction: We investigated whether the infiltration of tumor-infiltrating lymphocytes (TILs) in gastric cancer (GC), as evaluated by hematoxylin & eosin (H & E) staining, could be a prognostic marker. We also explored on the relationship between TILs and mechanistic target of rapamycin (mTOR) and how it regulates immune effector responses in GC.
Methods: A total of 183 patients with available data on TIL were included. TIL infiltration was evaluated using H & E staining. We also conducted immunohistochemistry to determine mTOR expression.
Results: Positive TIL infiltration was defined as TILs ≥20%. There were 72 (39.3%) and 111 (60.7%) positive and negative cases, respectively. TILs positivity significantly correlated with both absence of lymph node metastasis (p = 0.037) and negative p-mTOR expression (p = 0.040). TIL infiltration correlated with a significantly better overall (p = 0.046) and disease-free (p = 0.020) survival. Conclusion: mTOR possibly suppresses TIL infiltration in GC. H & E staining is an effective tool for evaluating the immune status of GC patients. H & E staining may be used in clinical practice to monitor treatment response in GC.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6