In:
Neuroendocrinology, S. Karger AG, Vol. 112, No. 4 ( 2022), p. 338-344
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Eating behavior is determined by both homeostatic and hedonic values. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We investigated the association of hedonic value with striatal dopamine transporter (DAT) availability sub-regionally. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 An intravenous bolus injection of 〈 sup 〉 18 〈 /sup 〉 F-FP-CIT was administered after the infusion of glucose or placebo, and the emission data were acquired over 90 min. DAT availability and binding potential (BP 〈 sub 〉 ND 〈 /sub 〉 ) were measured via the simplified reference tissue method. Subjects were assessed with sensory taste test of sucrose solutions. The “most liked” sucrose concentration (%) was determined as the hedonic rating for sucrose. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Twenty healthy males participated in this study. After glucose loading, BP 〈 sub 〉 ND 〈 /sub 〉 s of putamen significantly increased, and those of caudate nucleus showed the increasing trend, while those of ventral striatum were not significantly different. After glucose loading, the “most liked” sucrose concentration (%) was negatively associated with BP 〈 sub 〉 ND 〈 /sub 〉 s of caudate nucleus and showed the trend of positive association with those from ventral striatum. Slopes of regression lines were significantly different according to the sub-regions of striatum. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We have highlighted that striatal DAT increased after glucose loading in dorsal striatum, not in ventral striatum. These changes of striatal DAT were sub-regionally associated with the hedonic rating of sucrose from each subject.
Type of Medium:
Online Resource
ISSN:
0028-3835
,
1423-0194
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1483028-0
