In:
Pathobiology, S. Karger AG, Vol. 87, No. 4 ( 2020), p. 262-267
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 It has been reported that interferon-λ3 ( 〈 i 〉 IFNL3) 〈 /i 〉 might influence the pathogenesis and clearance of human papillomavirus (HPV) infection. The impact of 〈 i 〉 IFNL3 〈 /i 〉 single-nucleotide polymorphism (SNP) on HPV infection is currently unknown. The aim of this study was to investigate the association between variants in the 〈 i 〉 IFNL3 〈 /i 〉 region and HPV infection in women with human immunodeficiency virus (HIV) infection. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 236 HIV patients, including 65 HPV-negative and 171 HPV DNA-positive women, were enrolled into this study. The 〈 i 〉 IFNL3 〈 /i 〉 rs12979860 polymorphism was genotyped using a predesigned TaqMan SNP genotyping assay. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Data showed no significant differences in genotypes or allele frequencies between the HPV DNA-positive and the HPV-negative women ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.05). After dividing the HPV-positive women according to cytology results into patients with abnormal and normal lesions, the genotype and allele distribution of the SNP did not significantly differ between the 2 groups ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.05). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results showed that the 〈 i 〉 IFNL3 〈 /i 〉 rs12979860 polymorphism is not a major determinant of the susceptibility to HPV infection and their progression to abnormal cervical lesions in women living with HIV.
Type of Medium:
Online Resource
ISSN:
1015-2008
,
1423-0291
Language:
English
Publisher:
S. Karger AG
Publication Date:
2020
detail.hit.zdb_id:
1483541-1
SSG:
12