In:
Urologia Internationalis, S. Karger AG, Vol. 103, No. 1 ( 2019), p. 108-115
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The oestrogen antagonist tamoxifen has been suggested as an empiric treatment option for treating idiopathic oligoathenoteratozoospermia (iOAT). 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To analyse the use of tamoxifen in iOAT. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 Fifty-seven men receiving tamoxifen for iOAT were recruited from 2016 to 2017 in a retrospective, single-centre setting. Hormone and semen analysis was performed before and after 3 months of treatment. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 After a 3-month treatment, serum levels of testosterone (3.4 ng/mL [2.7–4.8] vs. 5.3 [3.1–7.1] ; 〈 i 〉 p 〈 /i 〉 = 0.026), follicle stimulating hormone (FSH; 7.6 [5.9–11.5] vs. 15.9 mIU/mL [8.4–19.9] ; 〈 i 〉 p 〈 /i 〉 = 0.003) and luteinizing hormone (4.5 [3.3–6.6] vs. 7.6 mIU/mL [4.8–10.7] ; 〈 i 〉 p 〈 /i 〉 = 0.007) significantly increased. At a cut-off of & #x3e;8.8 mIU/mL, serum levels of FSH were predictive for an improved sperm motility (OR 0.229 [95% CI 0.068–0.773]; 〈 i 〉 p 〈 /i 〉 = 0.018) and serum levels of inhibin B were predictive for an improved total sperm count at a cut-off of & #x3c;82 ng/L (OR 18.0 [95% CI 1.267–255.744]; 〈 i 〉 p 〈 /i 〉 = 0.033). During an 11 month-follow-up, patients receiving tamoxifen showed a clinical pregnancy rate of 42%, leading to a live birth rate of 56% of all pregnant women. Twenty-three per cent of all patients reported non-serious adverse events. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Tamoxifen is effective in improving the total sperm count as well as motility and can thus be safely used as empiric medical therapy in iOAT.
Type of Medium:
Online Resource
ISSN:
0042-1138
,
1423-0399
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1464417-4
