In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 79, No. 3 ( 2015), p. 160-167
Abstract:
〈 b 〉 〈 i 〉 Aim: 〈 /i 〉 〈 /b 〉 The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model. 〈 b 〉 〈 i 〉 Material and Method: 〈 /i 〉 〈 /b 〉 This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p 〈 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p 〈 0.008). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.
Type of Medium:
Online Resource
ISSN:
0378-7346
,
1423-002X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
1482695-1
