In:
Cardiology, S. Karger AG, Vol. 115, No. 3 ( 2010), p. 221-228
Abstract:
〈 i 〉 Objective: 〈 /i 〉 The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a mediator for inflammatory response in arteries. The present study investigated the relationship between atorvastatin and the 5-lipoxygenase pathway in an atherosclerotic rabbit model. 〈 i 〉 Methods: 〈 /i 〉 Thirty male New Zealand White Rabbits were randomized into negative control, positive control and atorvastatin groups. At week 4, the rabbits were subjected to carotid balloon-dilation injury or carotid balloon-dilation injury, followed by treatment with atorvastatin. At week 12, all the animals were sacrificed. Plasma lipids, LTD 〈 sub 〉 4 〈 /sub 〉 , and 15-epi-lipoxin A 〈 sub 〉 4 〈 /sub 〉 were measured using the enzymatic endpoint method and ELISA, respectively. RT-PCR was performed to detect the gene expression of 5-lipoxygenase-activating protein and cysLT1R in rabbit carotid arteries. Finally, histological analysis was used to evaluate the pathophysiological changes of rabbit carotid arteries. 〈 i 〉 Results: 〈 /i 〉 The results showed atorvastatin markedly lowered serum lipids and LTD 〈 sub 〉 4 〈 /sub 〉 levels compared with the control group. Similarly, mRNA expression of 5-lipoxygenase-activating protein and cysLT1R was significantly inhibited by atorvastatin. Decreased carotid plaque instability was evident in atorvastatin-treated animals, as demonstrated by a thickened elastic layer, less neointima hyperplasia and macrophage proliferation. 〈 i 〉 Conclusions: 〈 /i 〉 Atorvastatin may stabilize carotid plaque by regulating the 5-lipoxygenase pathway in atherosclerotic rabbits and delay the progression of atherosclerosis by exerting anti-inflammatory effects.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
80092-2
detail.hit.zdb_id:
1482041-9
