In:
Nephron Clinical Practice, S. Karger AG, Vol. 101, No. 2 ( 2005-6-15), p. c94-c99
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Fibroblast growth factor-23 (FGF-23) is a recently discovered phosphaturic factor. Although increased levels of serum FGF-23 have been reported in dialysis patients, the role of high FGF-23 levels remains unclear. Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy. 〈 i 〉 Methods: 〈 /i 〉 Thirty patients with severe secondary hyperparathyroidism were treated with intravenous calcitriol (0.5–1.0 µg) two or three times per week for 6 months. The changes of serum levels of calcium, phosphate, intact PTH, and FGF-23 were evaluated. 〈 i 〉 Results: 〈 /i 〉 Baseline serum FGF-23 levels were markedly high. By intravenous calcitriol therapy, intact PTH levels decreased effectively in the first month (p 〈 0.001). In contrast, FGF-23 levels increased gradually during the study period (p = 0.027). The Δ serum FGF-23 level was significantly correlated with the total doses of calcitriol injected intravenously in 6 months in patients with refractory secondary hyperparathyroidism (R 〈 sup 〉 2 = 〈 /sup 〉 0.147; p = 0.036). 〈 i 〉 Conclusions: 〈 /i 〉 Intravenous calcitriol decreased serum intact PTH level and increased serum FGF-23 levels significantly. Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D.
Type of Medium:
Online Resource
ISSN:
1660-2110
Language:
English
Publisher:
S. Karger AG
Publication Date:
2005
detail.hit.zdb_id:
2098336-0
