In:
European Neurology, S. Karger AG, Vol. 49, No. 4 ( 2003), p. 227-230
Abstract:
Although sporadic thyrotoxic periodic paralysis (TPP) has a much higher prevalence in Asian than in all the other populations studied so far, it is also increasingly being seen at the emergency departments of the West, hence, it is vital to stress the importance of recognizing it. TPP shares some similarities with hypokalemic periodic paralysis (HOKPP). However, the pathophysiology of TPP and the reasons for this higher incidence are not known. We hypothesized that some mutations in the 〈 i 〉 CACNA1S 〈 /i 〉 gene, which has been implicated in familial HOKPP, might play a role in TPP. We present 5 Chinese patients who suffer from TPP and demonstrate typical clinical features. No mutation was found on the whole 〈 i 〉 CACNA1S 〈 /i 〉 gene. Therefore other molecular mechanisms will have to be examined in order to explain the different TPP incidences.
Type of Medium:
Online Resource
ISSN:
0014-3022
,
1421-9913
Language:
English
Publisher:
S. Karger AG
Publication Date:
2003
detail.hit.zdb_id:
1482237-4
