In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 53, No. 2 ( 2002), p. 84-87
Kurzfassung:
〈 i 〉 Background: 〈 /i 〉 The association between thrombophilic variants (Leiden mutation of the factor V gene, G20210A mutation of the prothrombin gene and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene) with preeclampsia was investigated in a north-eastern Italian population. 〈 i 〉 Methods: 〈 /i 〉 Fifty-eight preeclamptic (PE) women and 74 normal pregnancies were evaluated. Genotypes were determined by polymerase chain reaction. 〈 i 〉 Results: 〈 /i 〉 The frequency of heterozygous carriers of the factor V Leiden was similar between PE women (5.2%) compared to the control subjects (4.1%; p 0.76). Also the frequencies of G20210A and C677T mutations were similar between PE and control subjects. 〈 i 〉 Conclusions: 〈 /i 〉 In this population, we found no difference in the prevalence of genetic risk factors for thrombosis in women with preeclampsia compared with control subjects.
Materialart:
Online-Ressource
ISSN:
0378-7346
,
1423-002X
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2002
ZDB Id:
1482695-1