In:
Stem Cells International, Wiley, Vol. 2023 ( 2023-4-4), p. 1-16
Abstract:
As double membrane-encapsulated nanovesicles (30-150 nm), exosomes (Exos) shuttle between different cells to mediate intercellular communication and transport active cargoes of paracrine factors. The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). Growing evidence has shown that MSC-Exos can be a potential candidate for treating IBD. In the present review, we summarized the most critical advances in the properties of MSC-Exos, provided the research progress of MSC-Exos in treating IBD, and discussed the molecular mechanisms underlying these effects. Collectively, MSC-Exos had great potential for cell-free therapy in IBD. However, further studies are required to understand the full dimensions of the complex Exo system and how to optimize its effects.
Type of Medium:
Online Resource
ISSN:
1687-9678
,
1687-966X
DOI:
10.1155/2023/4245704
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2573856-2