In:
Mediators of Inflammation, Wiley, Vol. 2016 ( 2016), p. 1-11
Abstract:
The present study is to measure the expression of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), as well as its clinical significance in cervical cancer patients. Our results showed that different T cell subsets in patients with cervical cancer had high expression of PD-1, and DCs had high expression of PD-L1. High expression of PD-1 on Treg cells in cervical cancer patients facilitated the production of TGF- β and IL-10 but inhibited the production of IFN- γ . Cervical cancer elevated the expression of PD-1 and PD-L1 in mRNA level. PD-1 expression in peripheral blood of cervical cancer patients was related with tumor differentiation, lymph node metastasis, and invasiveness. PD-1/PD-L1 pathway inhibited lymphocyte proliferation but enhanced the secretion of IL-10 and TGF- β in vitro. In summary, our findings demonstrate that elevated levels of PD-1/PD-L1, TGF- β , and IL-10 in peripheral blood of cervical cancer patients may negatively regulate immune response against cervical cancer cells and contribute to the progression of cervical cancer. Therefore, PD-1/PD-L1 pathway may become an immunotherapy target in the future.
Type of Medium:
Online Resource
ISSN:
0962-9351
,
1466-1861
DOI:
10.1155/2016/6891482
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1137605-3
detail.hit.zdb_id:
2008065-7
