In:
Cardiology Research and Practice, Hindawi Limited, Vol. 2015 ( 2015), p. 1-16
Abstract:
This systematic review with meta-analysis sought to determine comparison of efficacy and safety of hydration with sodium bicarbonate versus sodium chloride on contrast induced nephropathy and clinical outcomes. We searched major electronic databases for studies in randomized controlled trials. A value of P 〈 0.1 for Q test or I 2 〉 50 % indicated significant heterogeneity between the studies. Literature search of all databases retrieved 650 studies. 29 studies enrolled in meta-analysis. Pooled analysis indicated about the incidence of CIN (OR of 0.718; 95% CI: 0.60 to 0.85; P = 0.000 ), requirement of hemodialysis (OR of 1.00; 95% CI: 0.49 to 2.01; P = 0.9 ), mean changes of serum creatinine (WMD of 2.321; 95% CI: 1.995 to 2.648; P = 0.000 ), length of hospital stays (WMD of −0.774; 95% CI: −1.65 to 0.10; P = 0.08 ), major adverse cardiovascular events (OR = 1.075, 95% CI: 0.59 to 1.95; P = 0.8 ), and mortality (OR of 0.73; 95% CI: 0.42 to 1.26; P = 0.2 ). Overall, hydration with sodium bicarbonate could significantly reduce CIN and the length of hospital stay compared to sodium chloride. In addition NAC added as a supplement to sodium bicarbonate could increase prophylactic effects against nephropathy.
Type of Medium:
Online Resource
ISSN:
2090-8016
,
2090-0597
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2506187-2