In:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society, Vol. 325, No. 3 ( 2023-09-01), p. R280-R289
Abstract:
Whether sex hormones are related to pain perception across the menstrual cycle is unclear. We examined changes in experimental pain perception in healthy young females between the early to midfollicular subphase (emF) and the midluteal subphase (mL) and explored the role of sex hormones. Sixty-six participants were involved in the study. We tested pressure pain, cold pain, ischemic pain, and needle pain, while at the same time we measured sex hormones levels in two menstrual subphases. Only the right ulna pressure test showed a significant reduction in pain threshold (PPTh3) during the mL. The absolute change of PPTh3 (PPTh3 mL − PPTh3 emF ) was related to the absolute change of prolactin. The relative change of the range of pain tolerance for pressure pain of the right ulna (RPT3 rc ) was related to the relative change of progesterone (P rc ) and estradiol (E2 rc ) levels, and the interaction effects showed that at P rc ≤ 30, E2 rc was positively correlated with RPT3 rc . The same, the relative change of pressure pain tolerance of the pulp of the middle finger on the right hand (PPTo4 rc ) was related to E2 rc and P rc , and the results of the interaction between E2 rc and P rc suggest that when E2 rc is ≤0.8, P rc is positively correlated with PPTo4 rc . Two different formulas were applied in this study and showed inconsistent results. Most pain tests showed no difference between the two subphases of the menstrual cycle. Only the relative changes of the PPTo4 and RPT3 are related to the E2 rc and P rc , respectively, between menstrual subphases in an interactive way in healthy young women.
Type of Medium:
Online Resource
ISSN:
0363-6119
,
1522-1490
DOI:
10.1152/ajpregu.00275.2022
Language:
English
Publisher:
American Physiological Society
Publication Date:
2023
detail.hit.zdb_id:
1477297-8
SSG:
12
