In:
Journal of Biological Systems, World Scientific Pub Co Pte Ltd, Vol. 17, No. 03 ( 2009-09), p. 461-477
Abstract:
In intracellular mitogen-activated protein kinase (MAPK) cascades, it has been shown that signals can be propagated across the cell cytosol in the form of phosphoprotein waves arising from the bistable response of MAPK to active MAPK kinase. Without such a bistable response, however, they can not propagate into distant cell compartments, although a long positive feedback endows a mechanistically-distinct bistable response of MAPK to extracellular signal. Here we provide a compensate means that uses crosstalk between parallel identical pathways of MAPK cascades. For a spherical cell, we find that both unidirectional and bidirectional crosstalk with enhancement of phosphorylation can facilitate phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. Moreover, different shallow spatial gradients of biphosphorylated MAPK occur in the cytosol under different strengths of pathway interactions. These results suggest that crosstalk would be utilized by living organisms for spatial information transfer and cellular decision-making processing.
Type of Medium:
Online Resource
ISSN:
0218-3390
,
1793-6470
DOI:
10.1142/S0218339009002855
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2009
detail.hit.zdb_id:
2026740-X
SSG:
12
