In:
Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 5 ( 2023-10-17)
Abstract:
Klebsiella pneumoniae is a well-known human nosocomial pathogen that causes various infectious diseases, including urinary tract infections, hospital-acquired pneumonia, bacteremia, and liver abscesses. Our previous studies demonstrated that HiAlc Kpn mediated the development of nonalcoholic fatty liver disease by producing excess endogenous alcohol in vivo . However, the regulators regulating the expression of genes related to metabolism, biofilm formation, and virulence of HiAlc Kpn remain unclear. In this study, the regulator IHF was found to positively regulate biofilm formation and many virulence factors including CPS, LPS, type I and type III fimbriae, cellulose, iron transporter, AI-2 quorum sensing, T2SS, and T6SS in HiAlc Kpn . Furthermore, IHF positively regulated alcohol production in HiAlc Kpn . Our results suggested that IHF could be a potential drug target for treating various infectious diseases caused by K. pneumoniae . Hence, the regulation of different virulence factors by IHF in K. pneumoniae requires further investigation.
Type of Medium:
Online Resource
ISSN:
2165-0497
DOI:
10.1128/spectrum.01170-23
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2023
detail.hit.zdb_id:
2807133-5