In:
Journal of Clinical Microbiology, American Society for Microbiology, Vol. 54, No. 8 ( 2016-08), p. 2149-2154
Abstract:
Cytomegalovirus (CMV) enzyme-linked immunosorbent spot (ELISPOT) and CMV QuantiFERON assays were examined as potential biomarkers predictive of congenital CMV (cCMV) transmission. Fifty-seven pregnant women with primary CMV infection and 23 with nonprimary CMV infection were recruited in the study. Maternal age, CMV IgG avidity, viremia, and viruria were also included among the potential predictors. Spearman's statistical correlation analysis revealed a positive correlation between the CMV ELISPOT and CMV QuantiFERON assay results ( P 〈 0.001), but only the CMV ELISPOT assay correlated with cCMV ( P 〈 0.001). cCMV was positively correlated with maternal viremia and viruria ( P 〈 0.05) and negatively correlated with CMV IgG avidity ( P 〈 0.01). Maternal age and CMV QuantiFERON assay results were not statistically associated with cCMV. CMV-specific cell-mediated immunity detected by the CMV ELISPOT assay plays a critical role in cCMV.
Type of Medium:
Online Resource
ISSN:
0095-1137
,
1098-660X
DOI:
10.1128/JCM.00561-16
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2016
detail.hit.zdb_id:
1498353-9
detail.hit.zdb_id:
390499-4
SSG:
12