In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 12, No. 2 ( 1977-08), p. 255-260
Abstract:
The mode of action of 5-fluorocytosine on Candida albicans and Saccharomyces cerevisiae was studied with special reference to morphology and ultrastructure. Shortly after contact of yeast cells with 10 μg of 5-fluorocytosine per ml, marked enlargement of the cells occurred. The initial increase in cell size was almost the same with both yeast strains. As incubation proceeded, further increase in cell volume continued with C. albicans , whereas no further change in cell volume was observed with S. cerevisiae . An electron microscope examination of C. albicans cells after exposure to the drug revealed characteristic changes, consisting of an enlarged nucleus and a thin cell wall. The morphological changes were exactly comparable to those reported with inhibitors of deoxyribonucleic acid synthesis in mammalian cells and some bacteria.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.12.2.255
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1977
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
