In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 684 ( 2023-02-22)
Abstract:
The incidence of periodontal disease is high in individuals with rheumatoid arthritis (RA) who also have anti-citrullinated protein antibodies (ACPAs), suggesting a link between these two diseases. Brewer et al . carried out a paired analysis of human and bacterial transcriptomes from blood samples collected longitudinally from RA patients with and without periodontal disease. They identified transcriptional signatures within inflammatory monocyte subsets that correlated with repeated oral bacteremias and clinical arthritis flares in patients with RA and periodontal disease. These oral bacteria were broadly citrullinated, and some of these citrullinated epitopes were the targets of ACPA expressed by RA blood plasmablasts that have undergone affinity maturation. These results confirm that periodontal disease can cause breaches in oral mucosa that release citrullinated bacteria into the blood, which activates inflammatory monocytes and ACPA-specific B cells. —CF
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abq8476
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023