In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 78 ( 2022-12-23)
Abstract:
Langerhans cell histiocytosis (LCH) is an inflammatorymyeloid neoplasia seen in children and adults who present with lesions composedof pathologic variants of myeloid cells that share certain phenotypic featureswith Langerhans cells normally found in the epidermis. Kvedaraite et al. used deep profiling of cells from LCH tumors to compare them to normal myeloidsubsets and delve into their developmental origin. This analysis identified twoconvergent lineages of LCH cells featuring shared characteristics with the DC2and DC3/monocyte subsets of normal hematopoiesis. Signaling mediated by the Notchpathway enables these two cellular lineages to cooperatively form LCH lesions. These findings provide fresh insights into the origin of LCH and suggest newtargets for therapeutic approaches aimed at eliminating LCH cells afterdiagnosis. –IRW
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.add3330
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022