In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 8, No. 83 ( 2023-05-12)
Abstract:
Effective antitumor T cell responses are often hampered by the constraints of aberrant tumor-associated vasculature. Wang-Bishop et al . present an approach harnessing activation of the stimulator of interferon genes (STING) pathway to promote vascular normalization and enhance antitumor responses. They evaluated STING-activating nanoparticles (STANs) intravenously in multiple tumor models. STANs were able to normalize tumor vasculature and integrity, decrease tumor hypoxia, and promote expression of T cell adhesion molecules, which enhanced antitumor T cell infiltration and improved efficacy of immune checkpoint inhibitors and adoptive cell therapy. These findings suggest STANs to be a potential therapeutic approach that can target tumor vasculature and enhance effects of immunotherapy. —CNF
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.add1153
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023