In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 69 ( 2022-03-11)
Abstract:
Dendritic cells (DCs) are crucial components of immune responses, and their environment often dictates whether they are pro- or anti-inflammatory. Here, Tang et al. investigated the impact of Bat3, a protein that binds to Tim-3, in DC function in mouse models of experimental autoimmune encephalomyelitis (EAE) and cancer. Using mice with a knockout of Bat3 in DCs, they found that EAE was attenuated, but tumor growth was promoted. These effects were linked to a tolerogenic phenotype of Bat3 knockout DCs, which led to more anti-inflammatory T cells. Bat3 knockout in DCs was linked to an altered metabolic and unfolded protein response, leading to increased glucocorticoid production by DCs and subsequent T cell suppression. Thus, Bat3 regulates DC-mediated tolerance in the setting of autoimmunity and cancer.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abm0631
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022