In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 68 ( 2022-02-04)
Abstract:
Colonic goblet cells synthesize mucin glycoproteins secreted through exocytosis to form a mucosal barrier that separates the host epithelium and the luminal colonic microbiota. While analyzing the colonic mucosa in knockout mice lacking the pyroptosis-associated pore-forming protein Gasdermin D (GSDMD) in intestinal epithelial cells, Zhang et al. observed that the inner mucus layer normally associated with the apical epithelial surface was absent, resulting in a marked increase in the number of surface-attached bacteria. Epithelial goblet cells were still present at normal numbers but were defective in their ability to exocytose mucin granules to form the external mucus layer. These studies reveal an unanticipated physiological role for GSDMD in mucus export and establishment of the normal interface separating gut bacteria from colonic epithelial cells.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abk2092
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022