In:
Science, American Association for the Advancement of Science (AAAS), Vol. 381, No. 6662 ( 2023-09-08), p. 1049-1050
Abstract:
Cell-specific transcriptomic and epigenomic programming during human brain development and differentiation are associated with dynamic changes in chromosomal conformations, which provide a structural foundation for a myriad of nuclear functions. These functions include the compartmentalization of the genome into intranuclear environments that are either facilitative (open compartments) or repressive of transcription, as well as the activation or fine-tuning of gene expression through promoter-enhancer looping ( 1 , 2 ). However, a fine-grained analysis of the three-dimensional (3D) organization of neuronal genomes at the single-cell level and across the life span has been missing, particularly for the human brain. On page 1112 of this issue Tan et al. ( 3 ) report that the chromosomes of some neuronal populations show potentially lifelong progressive changes in conformation in mice and in humans.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.adk0961
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
SSG:
11
