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    Online Resource
    Online Resource
    Cigarette Craving, Smoking Withdrawal, and Clonidine
    American Association for the Advancement of Science (AAAS) ; 1984
    In:  Science Vol. 226, No. 4676 ( 1984-11-16), p. 864-866
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 226, No. 4676 ( 1984-11-16), p. 864-866
    Abstract: Clonidine, an α-2-adrenergic agonist, significantly reduces opiate withdrawal. Fifteen heavy smokers abstained from cigarettes on three separate occasions and received instead clonidine, placebo, or the benzodiazepine alprazolam. Clonidine and alprazolam diminished withdrawal symptoms. The two drugs suppressed anxiety, tension, irritability, and restlessness equally but clonidine had a greater effect than alprazolam on cigarette craving. These observations suggest that noradrenergic activity is a common feature in the pathophysiology of withdrawal and that a special relationship exists between central noradrenergic activity and craving.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.6387913
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 1984
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    SSG: 11
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