In:
The Journal of Physiology, Wiley, Vol. 596, No. 21 ( 2018-11), p. 5199-5216
Abstract:
We developed a novel method to study sympatholysis in dogs. We showed abolishment of sarcolemmal nNOS, and reduction of total nNOS and total eNOS in the canine Duchenne muscular dystrophy (DMD) model. We showed sympatholysis in dogs involving both nNOS‐derived NO‐dependent and NO‐independent mechanisms. We showed that the loss of sarcolemmal nNOS compromised sympatholysis in the canine DMD model. We showed that NO‐independent sympatholysis was not affected in the canine DMD model.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/tjp.2018.596.issue-21
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475290-6
SSG:
12