In:
The Plant Journal, Wiley, Vol. 99, No. 5 ( 2019-09), p. 950-964
Abstract:
Reactive oxidative species (ROS) and glutathione regulate plant cytosolic triosephosphate isomerases ( cTPI ) by targeting two reactive cysteines that function as thiol switches. Here we present the structural basis for cTPI inactivation by ROS and S ‐glutathionylation regulation. Our structures show how S ‐glutathionylation protects Atc TPI from irreversible chemical modifications while re‐routing carbon metabolism aimed to decrease oxidative stress.
Type of Medium:
Online Resource
ISSN:
0960-7412
,
1365-313X
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2020961-7
detail.hit.zdb_id:
1088037-9
SSG:
12