In:
Pediatric Anesthesia, Wiley, Vol. 24, No. 5 ( 2014-05), p. 505-509
Abstract:
The objective of this study was to determine ED 50 and ED 95 of remifentanil for intubation combined with propofol in nonparalyzed C hinese children. Methods Forty‐seven A merican Society of Anesthesiologists Class I children aged 4–11 years weighing 14–33.5 kg underwent general anesthesia with 2.5 mg·kg −1 of intravenous propofol followed by remifentanil in W enzhou, C hina. The initial dose of remifentanil was 2.5 μg·kg −1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg −1 . If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg −1 . Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED 50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg −1 of propofol in nonparalyzed C hinese children was 2.30 μg·kg −1 (95% confidence interval: 2.28–2.31 μg·kg −1 ), and the ED 95 is 2.75 μg·kg −1 (95% confidence interval: 2.59–3.35 μg·kg −1 ). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg −1 of intravenous propofol, ED 50 and ED 95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg −1 , respectively.
Type of Medium:
Online Resource
ISSN:
1155-5645
,
1460-9592
DOI:
10.1111/pan.2014.24.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2008564-3
