In:
Oral Diseases, Wiley, Vol. 28, No. 3 ( 2022-04), p. 631-638
Abstract:
To explore the prognostic value of systemic inflammatory biomarkers (albumin/globulin ratio [AGR], neutrophil/lymphocyte ratio [NLR] , and platelet/lymphocyte ratio [PLR]) in patients with oral squamous cell carcinoma (OSCC), and further develop a novel prognostic score (AGR‐NLR). Methods A large‐scale prospective study enrolling 792 eligible patients from December 2002 to June 2018 was carried out at the First Affiliated Hospital of Fujian Medical University. Three multivariate Cox regression models were performed to assess the association of overall survival (OS) with systemic inflammatory biomarkers, quantified by Akaike information criterion (AIC). Then, a novel AGR‐NLR score was established and incorporated into a prognostic nomogram. Results In the univariate analysis, the increased AGR was associated with a reduced risk of death. Conversely, the higher NLR and PLR, the worse the OS. In the multivariate Cox regression models, AGR and NLR were stably independent prognostic indicators in all models, with Model 2 showing a lowest AIC (AGR: HR = 0.56, 95%CI: 0.41–0.78; NLR: HR = 1.80, 95%CI: 1.07–3.04). Then, a novel AGR‐NLR score was established, which showed a more excellent performance than either AGR or NLR alone (area under curve [AUC]: 0.589, 0.559, and 0.556, respectively). The C‐index of the nomogram based on AGR‐NLR was superior to that of traditional TNM staging system (C‐index: 0.658 versus. 0.596, p 〈 .001). Similar results were also showed by decision curve analysis, indicating the nomogram had more positive net benefit compared to TNM staging system. Conclusion The novel AGR‐NLR score is strongly associated with outcome in patients with OSCC and could be serve as a useful tool to accurately predict the OS of OSCC patients.
Type of Medium:
Online Resource
ISSN:
1354-523X
,
1601-0825
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2008428-6
