In:
Neurology and Clinical Neuroscience, Wiley, Vol. 10, No. 1 ( 2022-01), p. 30-34
Abstract:
Glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune meningoencephalomyelitis. Case 1 is a 26–year‐old (yo) woman with a bilateral ovarian teratoma. She presented neck stiffness, hyperreflexia, bilateral postural tremor, and urinary retention. Three courses of a methylprednisolone pulse and subsequent enucleation of the bilateral ovarian teratoma improved her neurological symptoms with no recurrence. Case 2 is a 46‐year‐old man who showed infectious‐like symptoms with elevated creatine kinase. Case 3 is a 76‐year‐old man with preceding weight loss, a hyperintensity lesion in the hypothalamus, and increased uptake of the spinal cord, assessed by Fluorine 18 fluorodeoxyglucose positron emission tomography ( 18 F‐FDG PET). We compared the clinical features of the present three cases with previous reports. Consciousness disturbance, neck stiffness, tremors, and urinary dysfunction were observed in all three cases. These findings suggest widespread damage of the brain and spinal cord.
Type of Medium:
Online Resource
ISSN:
2049-4173
,
2049-4173
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2706717-8