In:
Mycoses, Wiley, Vol. 61, No. 1 ( 2018-01), p. 48-52
Abstract:
Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring Candida ‐reactive T cells as diagnostic read‐out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of a 56‐year‐old patient with HIV‐associated Burkitt lymphoma who developed septic shock during chemotherapy‐induced neutropenia. For the first time, we provide flow cytometry‐based diagnostics with Candida ‐reactive T cells for invasive candidiasis with comprehensive MRI imaging. The Candida ‐reactive T cell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment.
Type of Medium:
Online Resource
ISSN:
0933-7407
,
1439-0507
DOI:
10.1111/myc.2018.61.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
392487-7
detail.hit.zdb_id:
2020780-3