In:
Molecular Microbiology, Wiley, Vol. 89, No. 1 ( 2013-07), p. 113-122
Abstract:
A growing class of proteins regulates transcription through interaction with DNA ‐dependent RNA polymerase. Here we report that a recently identified, highly conserved sporulation gene ylyA encodes a novel RNA polymerase‐binding protein that influences the expression of genes under the control of the late‐acting, sporulation sigma factor σ G in B acillus subtilis. Spores from a ylyA mutant exhibited defects in germination corresponding to changes in the levels of membrane receptors for spore germinants and a protein channel governing the release of dipicolinic acid and hydration of the spore core during germination. Purified YlyA interacted with RNA polymerase and stimulated transcription from promoters dependent on σ G but not promoters dependent on the housekeeping sigma factor σ A . YlyA is a previously unrecognized RNA polymerase‐binding protein that is dedicated to modulating the expression of genes involved in spore germination.
Type of Medium:
Online Resource
ISSN:
0950-382X
,
1365-2958
DOI:
10.1111/mmi.2013.89.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1501537-3