In:
Microcirculation, Wiley, Vol. 24, No. 1 ( 2017-01)
Abstract:
The coronary arterial system consists of large epicardial coronary arteries, pre‐arterioles, and arterioles, which together closely regulate CBF. Structural, functional, and extravascular abnormalities of the microcirculation lead to CMD . CMD can present with symptoms suggestive of CAD , often in the absence of significant obstructive epicardial CAD . Conventional invasive angiography does not allow direct visualization of the microcirculation. Invasive indices, such as CBF and CFR , and non‐invasive imaging modalities, such as CMR and PET , can be used to quantify absolute MBF and enable a direct and accurate assessment of coronary microvascular function. CMD appears to be more prevalent in women, typically presenting with symptoms of ischemia with unobstructed coronary arteries, and has a relatively unfavorable prognosis. CMD is classified clinically depending on the presence or absence of epicardial CAD , myocardial disease, or iatrogenic causes. Although invasive intracoronary techniques can be used to detect CMD , these cannot provide insight into the mechanisms involved in its pathogenesis. Imaging modalities such as CMR and cardiac PET are becoming indispensable tools in the evaluation of suspected CMD .
Type of Medium:
Online Resource
ISSN:
1073-9688
,
1549-8719
DOI:
10.1111/micc.2017.24.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2008083-9
